In Dead Space 2 for the PS3 and Xbox 360, there are several things you can unlock for playing through the single player mode on Dead Space: Ignition, which is the prequel to the games.
Once you beat the single player mode on Dead Space: Ignition, in Dead Space 2 you’ll unlock a Hacker suit, a new Hacker skin for the Contact Beam, extra power nodes, extra health packs, extra credits, and even some audio logs.