Plague Inc – How to Beat Prion on Brutal

Prion on Brutal in Plague Inc. is probably the longest plague type I have played so far.

It took me a whopping 2064 days to beat this one, primarily because of Canada. I couldn’t swing a way to afford Drug Resistance 1 at the end without screwing myself.

I might have to work on this one later, but for now this one just requires a ton of patience.

Quick tip: Any time I mention devolving symptoms immediately, that means don’t close the notification first, go immediately to the symptoms page and devolve it, otherwise that brief second is enough time to alert the world that your plague exists, which makes beating the plague nearly impossible.

Also, purchasing anything outside of what’s listed in this guide may risk you not having enough points at the end, so don’t say I didn’t warn you!

Gene Setup for Prion on Brutal

DNA Gene: Metabolic Hack – Pops orange and red DNA bubbles automatically. This is a very long plague, so this ability allows you to set your phone down for a while and let the points come on their own.
Travel Gene: Teracyte – Increases the chance of your plague spreading by land.
Evolution Gene: Sympto-Stasis – Symptom costs don’t increase, but easier to cure, this one is important for this strategy.
Mutation Gene: Creationist – Decreases the chance of mutating symptoms, absolutely crucial for this really long plague type.
Environment Gene: Extremophile – Minor bonus in all environments.

Starting your Prion Plague

The basic strategy here, like most of the other plague types, is to remain undetected until everyone on the planet is infected, bank up some points, and then unleash hell upon the population.

Phase 1

• Start in India – Hot country with an airport and seaport
• Transmissions: Air 1, Water 1
• Symptoms: None, devolve all mutations immediately
• Abilities: Cold Resistance 1,

Phase 2

• Transmissions: Livestock 1
• Symptoms: None, devolve all mutations immediately
• Abilities: Cold Resistance 2

Phase 3

• Transmissions: None
• Symptoms: None, devolve all mutations immediately
• Abilities: Neural Atrophy 1, 2, and 3

Phase 4 

• Ride this out racking up points and devolving anything that pops up immediately
• Canada and Greenland will likely be the last to spread, and very slowly at that so you’ll be waiting on them for a while
• Once you have 63 points banked up and the entire world is infected, it’s time to finally destroy them!

Phase 5

• Time to unleash hell! Once everyone in the world is infected and you have at least 63 points, purchase Cysts, Hyper Sensitivity, Paralysis, Coma, and Total Organ Failure to start killing people off, and throw some extra points at fun stuff like Internal Hemorrhaging, Hemorrhagic Shock, and Necrosis if you have extra
• The cure will start to rise quickly, but don’t panic.. you’ll be racking up points quickly as well as the world dies off

Congrats, you win!