Plague Inc – How to Beat Prion on Normal with No Genes

Beating Prion on Normal in Plague Inc. is a little tough at first since it’s a fairly slow plague type. You’ll play it similar to how you played Fungus and Parasite, but the special ability isn’t nearly as good.

This is another “slow and go” plague type that takes a lot of time to spread, so be patient and don’t get too hasty.

Quick tip: Any time I mention devolving symptoms immediately, that means don’t close the notification first, go immediately to the symptoms page and devolve it, otherwise that brief second is enough time to alert the world that your plague exists, which makes your job a lot more difficult.

Gene Setup for Prion on Normal

I did this one with no genes selected, so feel free to add some if you’re having troubles, but it shouldn’t be tough at all if you follow this guide properly.

Starting your Prion Plague

Phase 1

• Start in India – Hot country with an airport and seaport
• Transmissions: Air 1, Water 1
• Symptoms: Cysts
• Abilities: Cold Resistance 1

Phase 2

• Transmissions: Livestock 1
• Symptoms: Devolve all mutations immediately
• Abilities: Cold Resistance 2

Phase 3

• Transmissions: None
• Symptoms: Devolve all mutations immediately
• Abilities: Neural Atrophy 1, 2, and 3

Phase 4 

• Ride this out racking up points and devolving anything that pops up immediately
• Countries like Canada and Greenland will likely be the last to infect and spread, so be patient and let your plague do its thing
• Once you have 70+ points banked up (you should have a lot more than that if you followed this closely) then it’s time to have some fun

Phase 5

• Time to unleash hell! Once everyone in the world is infected and you have about 70+ points, purchase Hyper Sensitivity, Paralysis, Coma, and Total Organ Failure to start killing people off, and throw some extra points at fun stuff like Internal Hemorrhaging, Hemorrhagic Shock, and Necrosis
• The cure will start to rise quickly, but don’t panic.. you’ll be racking up points quickly the population dies off
• Purchase Genetic Hardening and Genetic Reshuffle if you’d like to reduce the cure amount and increase your final score a bit

Congrats, you win!