In Resident Evil: Operation Raccoon City for the PS3 and Xbox 360, beating Tyrants can be tough at first, but you’ll eventually find them fairly easy once you figure out how to fight them properly.
The key to fighting Tyrants is to kite them. If you don’t know what kiting means, it’s means to run your ass off while they follow you and kill them in the process.
Tyrants aren’t overly fast unless they’re running. If they start running at you, get the hell out of the way.
Basically what you’re going to do is run away, turn around and blast them in the face as much as you can until they start to get close, then run away some more.
It sounds cowardly, but who cares.. it works.
Tyrants are actually really dumb, and you can exploit this sometimes. If you can get a car or two in between you and them, they will sometimes keep trying to walk through it while you blast them in the face.