The Nano Virus plague in Plague Inc. is a little tricky at first, because it’s much different then every other plague type.
The Nano Virus has a “kill switch” which basically just means that the world is kind of aware of your plague, and starts working on a cure immediately.
You’ll need to invest heavily in abilities and symptoms that slow down the cure, or else they’ll cure you before you’re done.
Gene Setup for Nano Virus on Normal
DNA Gene: Metabolic Jump – Get more DNA from popping red biohazard bubbles..
Travel Gene: Aquacyte – Increase the chance of your plague spreading by sea.
Evolution Gene: Patho-Stasis – Ability costs don’t increase, but easier to cure your plague.
Mutation Gene: Genetic Mimic – Your plague is harder to cure.
Environment Gene: Extremophile – Minor bonus in all environments.
Starting your Nano Virus
I like to start in India these days, because they are the second largest country, they have access to a seaport and airport, and it’s a hot country, which means you won’t really have to invest in Heat abilities.
Right off the bat you’re going to have to start slowing down the cure, because the kill switch starts immediately.
Purchase Code Fragment Interception and Radical Elements Stabilized on the Abilities page right as soon as you have points for them. Next purchase Code Segment Interception and Encryption Breached on Abilities as well. This will slow the kill switch work quite a bit.
Now that you have a little cushion, you can start spreading more. Purchase Air 1, Water 1, and Livestock 1 on Transmissions when you have enough points.
Take down some of the resistances by purchasing Drug Resistance 1 and Cold Resistance 1, and then Genetic Hardening 1 and 2 here as well to slow down the kill switch some more.
When you’ve spread some more and banked a few more points, purchase Air 2, Water 2, and Extreme Bioaerosol under Transmissions.
You should be making some good progress at this point. The cure will keep rising, but don’t panic yet because you should still have time. The end moves pretty quickly once the planet is infected.
A ton of points should be rolling in right about now. Purchase Drug Immunity, Drug Resistance 2, Cold Resistance 2, and all of the Genetic Reshuffles under Abilities. Also purchase Livestock 2 under Transmissions.
At this point most of the countries in the world should be infected. This is when I like to unleash Replication Factory Overload under Abilities to give your plague a huge boost in infectivity for a short period, but the side effect will be a reduction in Infectivity in the long run, which is ok because we’re about done spreading anyway. After you purchase Replication Factory Overload, you can purchase Drug Immunity as well to increase infectivity back up in wealthy countries.
Once everyone in the planet is infected, it’s time to unleash hell!
Purchase Cysts, Hypersensitivity, Paralysis, Coma, and Total Organ Failure.
Everything past this point should be gravy. Throw whatever you can at them to kill them off, choosing the symptoms with the highest Lethality when possible. I like to go up to Necrosis on the right side of the screen personally.
Congrats, you win!